Pharmacological investigation of subchronic administration with Scurrula atropurpurea some blood parameters and histopathology of brain, liver, heart, lung and kidney in rats

Abstract

Abstract

 

Objective: To evaluate whether Scurrula atropurpurea has a protection effect in the liver caused by its sub-chronic treatment

Materials and methods: The rats were divided in 4 groups: control group and three groups received methanolic extract of S. atropurpurea (MESA) at a dosage of 250; 500; and 1000 mg/KgBW. Serum liver and kidney function were assayed. Serum cholesterol were checked. Histopathology of brain, liver, cardiac, lung and kidney were identified using hematoxylin eosin staining.

Results: The administration of MESA250, MESA500 and MESA1000  caused no differences among the groups compared with the control group. Structural evaluations on brain and lungs showed that MESA administration carried no changes. In liver and heart, MESA1000  led to repair tissue damage. But for kidney, MESA250 was safe for the tissue.

Conclusion

 

The results of this study revealed that methanolic extract of S. atropurpurea at antihypertension dose is safe even when taken for a longer period. At a higher dose, the extract may have a potential to increase some hematological indices but may induce tissue repair in the liver and heart. The lowest dose is safe for kidney tissue.

Keywords

 

methanolic extract, sub chronic, hematology, histopathology