Evaluation of Antiplasmodial Activity of Flavanones from Macaranga hosei Leaves

Authors

  • Eva Marliana <p>Department of Chemistry, Faculty of Mathematics and Natural Sciences, Mulawarman University, Jl. Barong Tongkok 4 Samarinda 75123, East Kalimantan, Indonesia. Tel./Fax. +62-541-749140</p> <p> </p> Author
  • Tjitjik Srie Tjahjandarie Department of Chemistry, Faculty of Science and Technology, Airlangga University, Campus C Mulyorejo, Surabaya 60115, East Java, Indonesia. Tel./Fax. +62-31-5936502 Author
  • Mulyadi Tanjung Department of Chemistry, Faculty of Science and Technology, Airlangga University, Campus C Mulyorejo, Surabaya 60115, East Java, Indonesia. Tel./Fax. +62-31-5936502 Author

Abstract

Macaranga hosei is one of the species of Macaranga that widely distributed in tropical forest region including Indonesia. Several compounds from the leaves of this plant with broad spectrum of biological activities have been reported. This study was focus on antiplasmodial activity of four flavanones that have been isolated, named 4´-O-methyl-8-isoprenylnaringenin (1), lonchocarpol A (2), 4´-O-methyl-8-isoprenyleriodictyol (3) and 6-isoprenyleriodictyol (4). The antiplasmodial activity against Plasmodium falciparum 3D7 was conducted using Giemsa method. The most active compound was shown by 4 with IC50 value of 0.31 μg/mL, followed by 1, 2 and 3 with IC50 values of 1.02, 1.18 and 2.47 μg/mL, respectively.

Keywords: Macaranga hosei, antiplasmodial activity, flavanones, Plasmodium falciparum

Published

2018-09-01

Issue

Vol. 1 No. 1 (2018): The 1st ICoSTES 2018

Section

Poster